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Updated: Aug 11, 2025

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells
10:12

Visualization of G3BP Stress Granules Dynamics in Live Primary Cells

Published on: May 21, 2014

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様々なCMT2神経疾患は,ストレス粒子の異常なG3BP相互作用と関連している

Qinqin Cui1, Hongyun Bi1, Zhanyun Lv1

  • 1Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.

Cell
|February 4, 2023
PubMed
まとめ

環境ストレスにより,シャルコ・マリー・トゥース2型 (CMT2) 変異タンパク質がストレス粒に侵入し,細胞の反応を乱します. この相互作用をターゲットにすると,運動欠陥が軽減され,CMT2の病原性における共通リンクが明らかになる.

キーワード:
シャルコ・マリー・トゥース神経病G3BP についてアクソン変性環境ストレス遺伝的異質性モーターニューロン神経筋交差点外周神経症段階分離ストレス・グラニュル

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