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制御されていないBATF3誘発のCAR T細胞拡張に対するTET2保護

Nayan Jain1,2, Zeguo Zhao2, Judith Feucht2,3

  • 1Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.

Nature
|February 9, 2023
PubMed
まとめ

チメリック抗原受容体 (CAR) T細胞のTET2遺伝子を破壊すると,腫瘍の拒絶が強化されますが,危険で制御不能な細胞の成長のリスクがあります. TET2は,CAR T細胞療法におけるゲノム不安定を防ぎ,この増殖に対する守護者の役割を果たします.

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