哺乳類の皮質における細胞の温度コード
M Vestergaard1,2, M Carta3,4,5, G Güney6,7,8
1Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. mikkel.vestergaard@mdc-berlin.de.
Nature
|February 9, 2023
まとめ
研究者はマウスの特定の脳領域が 温度感覚を処理していることを特定しました 後部島皮質 (pIC) は,触覚とは異なり,冷たい刺激と暖かい刺激の両方をコードする主要な領域であるようです.
科学分野:
- 神経科学
- 感覚生理学
- ソマトセンシング
背景:
- 触覚とは異なる感覚形態で 特殊な神経経路があります
- 痛みを伴わない温度を皮質で表す方法はほとんど不明であり,専用の"熱皮質"をめぐる議論が続いている.
- 以前の研究では 熱刺激に反応する 限られた皮質ニューロンを特定しました
研究 の 目的:
- 痛みを伴わない温度刺激 (冷却と加熱) の皮質のエンコーディングを調査する.
- 特定の脳領域と 熱知覚を司るニューロンの集団を特定する
- 皮質内の熱表現の空間と時間の特性を決定する.
主な方法:
- ワイドフィールドと2フォトンのカルシウムイメージング技術をマウスの前足モデルで利用した.
- 制御された冷却と暖房刺激に対する神経活動の記録
- 熱感への影響を評価するために,可逆操作技術を使用した.
主要な成果:
- 冷却と/または温暖化に反応する異なる皮質ニューロン集団を特定した.
- 主要な体感皮質では 冷たい刺激が表れるが 暖かい刺激は表れない
- 後部島皮質 (pIC) で冷たい刺激と暖かい刺激の両方の 頑丈で体形的に組織された表現が見つかりました
結論:
- 後部島皮質 (pIC) は,皮膚の温度を表す主要な皮質領域として機能する.
- 寒冷と暖かい気温の情報は 同じニューロンの内部でも 明確にコード化されています
- この発見は 脳が冷やし 暖かい感覚を どのようにして生み出すのか 洞察力を与えてくれます
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