タクソン特異的な,段階化されたsiRNAは,猿の花の種化場所の基礎となっている
Mei Liang1, Wenjie Chen1,2, Amy M LaFountain1
1Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA.
Science (New York, N.Y.)
|February 9, 2023
まとめ
マンキーフラワーの重要な種化遺伝子である YELLOW UPPER (YUP) は,花の色を調節する小さなRNAを生成します. この遺伝的位置がミミュラスの表型多様化と 授粉者主導の種の形成を促します
科学分野:
- ゲノミクス
- 進化生物学
- 分子生物学
背景:
- 小さなRNAロキは真核生物に多く見られるが,その種の形成における役割は不明である.
- フェノタイプの多様化と特異化の遺伝的基礎は,進化生物学における重要な問題である.
研究 の 目的:
- マンキーフラワー (Mimulus) の種化における YELLOW UPPER (YUP) の役割を調査する.
- 小型RNAがフェノタイプの多様化と生殖分離にどのように貢献するのかを理解する.
主な方法:
- YUPの場所構造の分析,反転した繰り返し領域を含む.
- YUPによって生成される小さな干渉RNA (siRNA) の識別と特徴付け.
- 花の色素化遺伝子を調節する siRNA 機能の標的予測と検証
主要な成果:
- YUPロカスには,相性 siRNAsを生成する反転したリピートが含まれています.
- YUPから派生した1つのsiRNAは,花のカロテノイド生物合成の重要なレギュラーを標的にし,抑制する.
- YUPは花の色付けのためのタンパク質をコードする遺伝子を含み,ミミュラスの"スーパーロカス"として機能します.
結論:
- YUPの位置は,猿の花の表型多様化と種化に重要な役割を果たしています.
- siRNAは,非コーディング領域から発生し,色素化遺伝子を調節し,進化的適応に貢献することができます.
- YUPの"スーパーロカス"は 遺伝的イノベーションが 種の進化を促す仕組みを理解するためのモデルです
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