関連する実験動画

Updated: Aug 11, 2025

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

9.1K

BIRC6クライアント複合体の構造は,SMAC媒介によるカスパスの放出メカニズムを提供します

Moritz Hunkeler1,2, Cyrus Y Jin1,2, Eric S Fischer1,2

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Science (New York, N.Y.)
|February 9, 2023
PubMed
まとめ

アポトーシスタンパク質の阻害剤 (IAP) は細胞死を調節する. この研究は,BIRC6の構造を明らかにし,SMAC結合がカスパスを抑制し,アポトーシス調節とがん治療の洞察を提供している.

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