過剰に興奮した辺縁神経は,性的な飽和感を表し,交尾の動機を低下させます
Xiaojuan Zhou1, Ang Li1,2, Xue Mi1
1Chinese Institute for Brain Research, Beijing 102206, China.
まとめ
性的経験は脳の回路を変化させ 交尾意欲を永久に変えてしまう 排泄は,ストリア・ターミナリス (BNST) のベッド核の特定のニューロンを活性化させ,性的な飽和感と動機を低下させます.
科学分野:
- 神経科学
- 行動生物学
- 内分泌学
背景:
- 短期的な性的経験は 長期的な行動の変化を誘発します
- これらの持続的な効果の根底にある神経メカニズムは,ほとんど未知のままです.
研究 の 目的:
- 性的経験による 行動変化の 神経コードを調査する
- 性的な飽和感と交配意欲に関与する特定のニューロン集団と分子機構を特定する.
主な方法:
- 排泄が神経活動に及ぼす影響を研究するために ネズミのモデルを使用した.
- ニューロンの活性化/阻害,電気生理学,行動分析を含む技術を使用した.
- エストロゲン受容体2 (Esr2) を発現するニューロンの作用を研究した.
主要な成果:
- 排泄は,エストロゲン受容体2 (BNSTEsr2) を発現するBNSTニューロンを選択的に活性化する.
- この活性化により ニューロンの発火値が持続的に低下し 性的飽和感が引き起こされた.
- 過剰興奮したBNSTEsr2ニューロンの抑制により,飽和したマウスの交尾行動が急速に回復した.
- 男性では,BNSTEsr2の過剰興奮が交配の動機を低下させ,部分的にはハイパーポラライゼーション活性化サイクルヌクレオチドゲート (HCN) 流によって媒介された.
結論:
- BNSTEsr2ニューロンは 交尾行動だけでなく 性的な飽和状態もコードします
- ニューロンのイオンチャネルの変化は 性的経験の後の交尾衝動の長期的な変化に寄与する.
- これらの発見は 性的出会いの後の 行動の可塑性の 神経的基盤に 洞察を与えてくれます
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