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Updated: Aug 10, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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2エチニルベンザルデヒド基,ライシン標的のタンパク質キナーゼおよびノンキナーゼの不可逆的共性阻害剤

Peng Chen1, Guanghui Tang2, Chengjun Zhu3

  • 1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.

Journal of the American Chemical Society
|February 12, 2023
PubMed
まとめ

この研究は,選択的,細胞活性ライシン標的の不可逆的共性阻害剤の作成のための新しい2エチニルベンザルデヒド (EBA) ベースの戦略を導入します. このアプローチは,ABLキナーゼ,EGFR,Mcl-1に対する強力な阻害剤を成功裏に生成し,広範な適用性を示した.

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