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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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ビルモラコニチンの総合成

Jiujian Ji1, Jiajun Chen1, Sixun Qin1

  • 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.

Journal of the American Chemical Society
|February 13, 2023
PubMed
まとめ

研究者らは,複雑なC19-ディテルペノイドアルカロイドであるヴィルモラコニチンの最初の完全な合成を達成しました. 独特のヘプタサイクルの核を作るために 新しい環形成反応を活用しました

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