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Updated: Aug 9, 2025

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
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人間の Na-Cl コトランスポーターの構造とチアジド阻害機構

Minrui Fan1, Jianxiu Zhang1, Chien-Ling Lee1

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|February 15, 2023
PubMed
まとめ

研究者は,塩化ナトリウムコトランスポーター (NCC) の構造と,チアジド性尿薬との相互作用を決定した. これはNCCの機能,調節,高血圧薬のメカニズムに関する重要な洞察を示しています.

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