Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

964
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
964
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

712
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
712
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

604
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
604
Antigen Processing Pathways01:31

Antigen Processing Pathways

1.2K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
1.2K
Antigen Presenting Cells01:22

Antigen Presenting Cells

2.0K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
2.0K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

69.6K
Overview
69.6K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A transient epithelial plasticity state defines the developmental window for uterine gland specification.

bioRxiv : the preprint server for biology·2026
Same author

Spatiotemporal cellular map of the developing human reproductive tract.

Nature·2025
Same author

A novel paradigm for single-cell annotation in stem cell research.

Stem cell reports·2025
Same author

Protocol for a human placental explant model to study acute responses to pathogens.

STAR protocols·2025
Same author

Atlas of amnion development during the first trimester of human pregnancy.

Nature cell biology·2025
Same author

How machine learning can help us understand what we have grown in the dish.

Nature reviews. Molecular cell biology·2025
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Aug 9, 2025

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.1K

異種抗原の解読耐性

Roser Vento-Tormo1,2

  • 1Wellcome Sanger Institute, Cambridge, UK.

Science (New York, N.Y.)
|February 16, 2023
PubMed
まとめ
この要約は機械生成です。

細胞アトラスはヒトの耐性環境をマッピングし 新しい免疫療法への道を開いている. これらの免疫抑制組織の詳細な地図は 先進的な治療法の開発に不可欠です

さらに関連する動画

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.4K

関連する実験動画

Last Updated: Aug 9, 2025

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.1K
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

10.8K
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

14.4K

科学分野:

  • 免疫学
  • 細胞生物学
  • 医学 研究

背景:

  • 自己免疫疾患の治療と 臓器移植を可能にするには 免疫耐性を理解することが重要です
  • ヒトの耐受性環境に関する既存の知識は限られており,標的型免疫療法の開発を妨げています.

研究 の 目的:

  • ヒトの許容性のある環境の包括的な細胞アトラスを作成する.
  • これらのアトラスを活用して 新しく変革的な免疫療法を設計する

主な方法:

  • 細胞の組成と状態をプロファイルするために単細胞RNA配列化.
  • 組織構造と細胞間の相互作用を理解するための空間的トランスクリプトミクス
  • マルチオームデータを統合し,重要な規制経路を特定するためのバイオ情報分析.

主要な成果:

  • ヒトの許容性のある環境における細胞の詳細な特徴
  • 免疫抑制に関連する新しい細胞サブセットと分子シグネチャの識別.
  • 免疫ホメオスタシスを維持する細胞相互作用のマッピング

結論:

  • 細胞アトラスは ヒトの免疫耐性に関する 前例のない洞察力を提供します
  • これらのアトラスは,次世代の免疫療法の開発を導くための基本的なリソースとして機能します.
  • 特定された経路と細胞タイプをターゲットにすることで 臨床翻訳の見込みがある.