進行したHIV感染者におけるMpox: 世界的な症例シリーズ
Oriol Mitjà1, Andrea Alemany1, Michael Marks2
1Skin Neglected Tropical diseases and Sexually Transmitted Infections section, Fight Infectious Diseases Foundation, University Hospital Germans Trias i Pujol, Badalona, Spain.
Lancet (London, England)
|February 24, 2023
まとめ
Mpoxは2022年の流行でHIVに感染した人々に不均衡な影響を及ぼしました. 進行したHIVと低CD4数 (<200細胞/mm3) は,重度のmopox合併症と,エイズを定義する疾患に類似した高い死亡率と関連していた.
科学分野:
- 感染症
- ウイルス学
- 免疫学
背景:
- モンキーポックス (monkeypox) は,2022年の多国間流行の間にHIV感染者 (PLWH) に著しく影響を与えた.
- 多くのPLWHでは,HIVのない患者と同様のアウトカムが認められたが,新しいデータは,進行したHIV患者の臨床アウトカムが悪化したことを示した.
- この研究では,低CD4細胞数 (<350細胞/mm3) のPLWHにおけるmopoxの臨床特性とアウトカムに焦点を当てた.
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