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バクテリアのcGASによるウビキチンのような結合は,抗菌体防御を強化する

Justin M Jenson1,2, Tuo Li1,2,3, Fenghe Du1,2,3

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature
|February 27, 2023
PubMed
まとめ

細菌はファグの感染に対するcGAS酵素の活性を制御するために,ユビキチンのようなメカニズムを使用します. これは,循環性GMP-AMP (cGAMP) の生成を促進するタンパク質結合を伴うもので,ファージはcGAMPを隔離することで,それを抵消する.

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