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Updated: Aug 8, 2025

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β2マイクログローブリンは内生的なNMDAR抗体として作用し,シナプス機能を損なう

Yue Gao1, Yujuan Hong2, Lihong Huang2

  • 1State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Department of Neurology, the First Affiliated Hospital of Xiamen University, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, Fujian 361005, China; Shenzhen Research Institute of Xiamen University, Shenzhen, Guangdong 518057, China.

Cell
|March 3, 2023
PubMed
まとめ

ダウンの症候群 (DS) の脳障害の原因は血液因子です. 血のベータ2マイクログローブリン (B2M) が増加すると,NMDA受容体 (NMDARs) を阻害することでシナプス機能が低下し,B2Mが治療標的となる可能性がある.

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