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Updated: Aug 7, 2025

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メカノおよびリガンド依存的粘着GPCR解離の分子センシング

Nicole Scholz1, Anne-Kristin Dahse2, Marguerite Kemkemer2

  • 1Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Leipzig, Germany. scholzlab@gmail.com.

Nature
|March 8, 2023
PubMed
まとめ

粘着Gタンパク質結合受容体 (aGPCRs) は,機械的な力とリガンドの相互作用によって影響されるプロセスであるオートプロテオリシスを受けます. この解離は神経発達に不可欠な非細胞自律的機能を可能にし 潜在的薬物標的となる.

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