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Updated: Aug 6, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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全ゲノム倍増は,腫瘍性クロマチン分離の損失を誘発する

Ruxandra A Lambuta1,2, Luca Nanni2,3,4, Yuanlong Liu2,3,4

  • 1Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Écublens, Switzerland.

Nature
|March 16, 2023
PubMed
まとめ

全ゲノム倍化 (WGD) は,p53欠乏した癌細胞におけるクロマチンの分離 (LCS) の喪失を引き起こします. この染色体の再編成は表遺伝的変化によって引き起こされ,腫瘍遺伝子の活性化と腫瘍の進行を促進し,WGDによって引き起こされるがんにおける染色体の進化を強調する.

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