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Updated: Aug 6, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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14-3-3/ERRγタンパク質-タンパク質相互作用の可逆二重共振分子ロックが分子接着剤薬剤発見方法として

Bente A Somsen1, Rick J C Schellekens1, Carlo J A Verhoef1

  • 1Laboratory of Chemical Biology, Department of Biomedical Engineering, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Journal of the American Chemical Society
|March 17, 2023
PubMed
まとめ

研究者たちは タンパク質とタンパク質の相互作用 (PPI) を 安定させる 二重共性分子である"分子鎖"を開発しました このアプローチは分子接着剤の薬剤発見と生体物理学の研究のためのツール化合物を迅速に生成します

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