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Updated: Aug 6, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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システインカルボキシエチル化により,HLA制限による自己免疫を誘発するネオアンチゲンが生成される

Yue Zhai1, Liang Chen2, Qian Zhao3

  • 1Department of Clinical Immunology, Xijing Hospital, and Department of Cell Biology of National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an 710032, China.

Science (New York, N.Y.)
|March 17, 2023
PubMed
まとめ

メタボライト誘発のシステインカルボキシエチル化により,縮性脊髄炎 (AS) の新抗原が生成されます. これらのネオアンチゲンは自己免疫反応を引き起こし,AS患者のT細胞活性化と自己抗体生成につながります.

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