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テラムスは,ゼブラ・フィンチの求愛歌の発声を促す
Felix W Moll1,2,3, Devorah Kranz1,2, Ariadna Corredera Asensio1,2
1NYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY, USA.
Nature
|March 23, 2023
まとめ
声の配列を制御する
科学分野:
- 神経科学
- 行動生物学
- 聴覚神経科学
背景:
- 遠隔のインプットは,モーター皮質の回路におけるアクション実行に決定的な影響を及ぼします.
- タラミック投影は前運動活動を形作り,複雑な行動のためのステレオタイプの行動を選択する可能性があります.
研究 の 目的:
- 連続運動の実行におけるタラムス-モーター皮質の相互作用のメカニズムを調査する.
- 声の配列の進行におけるタラミック・インプットの役割を決定する.
主な方法:
- ゼブラフィンチのHVC (本名) 曲核におけるタラミックアクソンの2光子のインビボ画像.
- 歌うときのタラミック機能のオンラインの混乱.
- HVCにおけるタラモレシピエントニューロンの特定と特徴づけのためのタラミック刺激.
主要な成果:
- タラミック・ドライブは,HVC前運動ニューロンの特定のサブ集団 (~15%) を誘発する.
- これらのタラモレシピエントニューロンは 音節発現の前に活性化します
- 混乱したタラミック機能が 音節の境界で曲を切り離す
結論:
- 音声モーター要素 (音節) の間の進行にはタラミック入力が不可欠です.
- タラモスは,HVC内の特定の"スタートセル"をターゲットにすることで,ソングコンポーネントを開始することができます.
- 運動性タラムスは 連続的な行動における 皮質のダイナミクスのディレクターとして機能します
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