関連する実験動画

Updated: Aug 6, 2025

Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart
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Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart

Published on: August 10, 2018

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内皮のHDAC1-ZEB2-NuRD複合体は,タンパク質S-硫黄水分を調節することによって大動脈動脈瘤と解剖を駆動する

Shanshan Luo1, Chuiyu Kong1, Shuang Zhao1

  • 1Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School (S.L., C.K., S.Z., Xin Tang, Y.W., X.Z., R.L., X.L., S.S., A.G., L.X., Y.J.), Nanjing Medical University, China.

Circulation
|March 23, 2023
PubMed
まとめ

内皮のタンパク質S-硫化が減少すると,大動脈解剖のリスクが増加します. ZEB2-HDAC1-NuRD複合体は このプロセスを阻害し 病気を誘発します この経路をターゲットにすることで,大動脈動脈瘤と解剖 (AAD) を防ぐことができます.

キーワード:
大動脈動脈瘤大動脈の解剖エンドセリウムガストランスミッター翻訳後の修正

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