重篤な感染と心血管疾患のリスク: 多集団研究
Pyry N Sipilä1,2, Joni V Lindbohm1,3, G David Batty3
1Departments of Public Health (P.N.S., J.V.L., S.T.N., J.P., M.K.).
Circulation
|March 27, 2023
まとめ
重篤な感染症は,短期的および長期的な主要な心血管疾患のリスクを大幅に高めます. この関連は心臓病や脳卒中を予防するために 感染症の管理が重要であることを強調しています
科学分野:
- 心臓病科
- 感染症
- 流行病学
背景:
- 様々な感染症と心血管疾患 (CVD) のリスクとの関連は完全に理解されていません.
- 重度の感染症に伴う短期的および長期的CVDリスクを定量化することは公衆衛生にとって極めて重要です.
- 感染による心血管疾患の割合を推定することで,予防戦略を策定できます.
研究 の 目的:
- 重度の感染症の後に起こる 重度の心血管疾患の短期的および長期的リスクを定量化する.
- 重度の感染症に関連する心血管疾患の割合を推定する.
主な方法:
- イギリスのバイオバンクデータ (331,683人の参加者) を利用し,フィンランドのコホートデータ (271,329人の参加者) での結果を複製した.
- 診断された感染症の後に発生した重大な心血管疾患 (心筋梗塞,心臓死,脳卒中) の評価
- 心血管リスク要因を制御した,調整された危険比率 (HRs) と人口分数.
主要な成果:
- 感染症による入院は,感染の種類に関係なく,主要な心血管疾患のリスクの増加と関連していました.
- 感染後最初の1ヶ月でリスクが最も高かった (HR: 7. 87 UK Biobank, 7. 64 フィンランド) が,長期的には高かった (HR: 1. 47 UK Biobank, 1. 41 フィンランド).
- 重度の感染症は,人口の4. 4% (英国バイオバンク) と6. 1% (フィンランド) を占めた.
結論:
- 病院で治療された感染症は,重大心血管疾患の直接的および長期的なリスクを大幅に高めます.
- 重度の感染症の心臓血管への影響を強調しています.
- 長期的リスクの観察では,残留混同を完全に排除することはできません.
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