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Updated: Aug 5, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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標的型タンパク質の分解をオンデマンドで終了する

Yuhui Jin1,2, Jing Fan1,2, Ruyan Wang1,2

  • 1Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University; Nanjing 210009, China.

Journal of the American Chemical Society
|March 27, 2023
PubMed
まとめ

研究者は,タンパク質分解を標的とするキメラ (PROTAC) の分解を制御するための新しい"スキャベリングへの結合"システムを開発しました. この方法は,TCO 改変型デンドリマーを使用して PROTAC を除去し,生体細胞内のオンデマンドのタンパク質をノックダウンします.

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