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Updated: May 8, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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標的生物分子の規制プラットフォーム:分割して混合するPROTACアプローチ

Fenfang Yang1, Qinhong Luo1,2, Yuechen Wang1

  • 1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of the American Chemical Society
|March 31, 2023
PubMed
まとめ

新しいスプリット・アンド・ミックス・ナノプラットフォームは,標的型RNA分解とタンパク質分解のための二機能分子の作成を簡素化します. このプラットフォームは,スプリット・アンド・ミックス・プロテオリシス・ターゲティング・キメラ (SM-PROTAC) により実証され,多様な治療用途のためのプログラム可能な制御を提供します.

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関連する概念動画

Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...