関連する実験動画

Updated: Aug 4, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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グルカゴン受容体のRAMP2による負アロステリック調節

Kaavya Krishna Kumar1, Evan S O'Brien1, Chris H Habrian1

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, CA 94305, USA.

Cell
|March 31, 2023
PubMed
まとめ

受容体活性調節タンパク質2 (RAMP2) は,受容体の柔軟性を高めることで,グルカゴン受容体 (GCGR) のシグナル伝達を阻害する. この相互作用は GCGR を破壊する.

キーワード:
Gタンパク質Gタンパク質結合受容体GPCR についてHDX-MS についてアロステリーセル信号クリオ・エムクリオ電子顕微鏡グルカゴン受容体質量スペクトロメトリーで監視された水素-デュテリウム交換タンパク質の動態レセプター活性調節タンパク質RAMP単一分子の光共振エネルギー転送smFRET について

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