関連する実験動画

Updated: Aug 3, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
09:47

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates

Published on: May 10, 2022

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SCFユビキチンリガゼ複合体のシステム全体の解体と組み立て

Kheewoong Baek1, Daniel C Scott2, Lukas T Henneberg1

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.

Cell
|April 7, 2023
PubMed
まとめ

CAND1タンパク質は,CUL1サブユニットをリサイクルして,SCFユビキチンリガース複合体を組み立て,タンパク質の分解と細胞反応に不可欠です. このメカニズムは,精密なE3リガース活性化のためにSCF成分を効率的に混合し,マッチングすることができます.

キーワード:
CAND1 についてCRLE3リガゼNEDD8 についてSCF についてクリオ・エムクリン・リング・リガゼタンパク質複合体の組成プロテオミクスユビキチン

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