Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

1.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.1K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

617
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
617
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

220
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
220

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A Personalized Medicine Approach: Psychosocial and Genetic Risk Assessments Predictors of Bariatric Surgery Outcomes After 3 Years.

Biomedicines·2026
Same author

Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age.

Pediatrics·2026
Same author

Association of Blood Arsenic Concentrations with Lipid Markers in Uruguayan Adolescents: Exploring Effect Modification by Body Mass Index and Sex.

Exposure and health·2026
Same author

Exposure to a mixture of four metals and associations with urinary oxidative stress biomarkers in Uruguayan adolescents.

Journal of environmental exposure assessment·2026
Same author

Type 1 diabetes screening: reframing the debate from paternalism to partnership. Reply to Scaramuzza AE, Iafusco D, Cherubini V [letter] Type 1 diabetes screening: building a clinician-patient partnership for early care of chronic beta cell failure. Reply to Mallone R, Bandini A [letter].

Diabetologia·2026
Same author

Diabetes-Related Hospitalizations From 2018-2023 for Children With Type 2 Diabetes.

Hospital pediatrics·2026

関連する実験動画

Updated: Aug 3, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.8K

1 型糖尿病

Teresa Quattrin1, Lucy D Mastrandrea1, Lucy S K Walker2

  • 1Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Diabetes Center, John R Oishei Children's Hospital, Buffalo, NY, USA.

Lancet (London, England)
|April 8, 2023
PubMed
まとめ
この要約は機械生成です。

1型糖尿病は,インスリン生成細胞の自己免疫破壊を伴う. 最近の研究では これらの細胞を保護して インスリン生成を保ち 予防と治療の新たな希望を示しています

さらに関連する動画

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.8K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.5K

関連する実験動画

Last Updated: Aug 3, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
06:27

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

16.8K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.8K
Electrochemiluminescence Assays for Human Islet Autoantibodies
09:15

Electrochemiluminescence Assays for Human Islet Autoantibodies

Published on: March 23, 2018

15.5K

科学分野:

  • 免疫学
  • 内分泌学
  • 代謝 疾患

背景:

  • 1型糖尿病は慢性的な自己免疫疾患で,臓のベータ細胞を標的とし,生涯にわたるインスリン治療を必要とします.
  • 複雑な病理生理学 (遺伝的,免疫的,環境的要因) を理解する進歩にもかかわらず,病気の負担は依然として大きい.
  • 現在の治療法では 症状は治りますが 病気の進行を止めることも 治療もできません

研究 の 目的:

  • 1型糖尿病 (T1D) 研究の包括的なレビューを提供すること.
  • T1Dの病理生理学,治療,管理の最近の進歩を強調する.
  • 臨床ケアにおける現在の課題を議論し,予防,管理,治療のための将来の研究方向性を探求する.

主な方法:

  • 1型糖尿病に関する最近の研究の文献レビュー (過去5年以内)
  • ベータ細胞保存をターゲットとした免疫調節戦略に関する研究の分析.
  • 臨床ケアにおける課題と新たな治療方法に関する情報の統合

主要な成果:

  • 新興の研究は,リスクのある個人または早期発症のT1D患者の内生インスリン産生を維持するための免疫調節アプローチの可能性を実証しています.
  • T1D に寄与する遺伝的,免疫的,環境的要因の 複雑な相互作用を理解する上で 顕著な進展がありました
  • 進歩にもかかわらず,高い病気の負担は継続しており,より効果的な介入の必要性を示しています.

結論:

  • 標的型免疫介入による内生性インスリン生成の維持は,T1Dの管理と潜在的に疾患の進行を停止する見込みを示しています.
  • 臨床ケアにおける課題を克服し,1型糖尿病の予防,効果的な管理,最終的な治療のための戦略を開発するには,継続的な研究が不可欠です.
  • 将来の方向性は,免疫調節療法を精製し,T1Dの多面性に対処するための新しいアプローチを探求することです.