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Updated: Aug 3, 2025

Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
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Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion

Published on: September 13, 2024

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クロモソームの脆弱な部位は,クラスター化された繰り返しでEBNA1によって破裂する

Julia Su Zhou Li1,2, Ammal Abbasi3,4,5, Dong Hyun Kim6,3,7

  • 1Ludwig Cancer Research, UC San Diego, La Jolla, CA, USA. juliali@health.ucsd.edu.

Nature
|April 12, 2023
PubMed
まとめ

エプスタイン・バーウイルス (EBV) のタンパク質EBNA1はヒト染色体11に結合し,DNA破裂とゲノム不安定を引き起こします. この断裂は,EBVに関連した癌における染色体11の再配置と関連しています.

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