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Updated: Jun 7, 2026

Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons
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Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

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細胞のないシステムの精密で正方形の遠隔制御は,光ケージ化された核酸を使用します

Giacomo Mazzotti1, Denis Hartmann1, Michael J Booth1,2

  • 1Department of Chemistry, University of Oxford, Mansfield Road, OX1 3TA Oxford, U.K.

Journal of the American Chemical Society
|April 19, 2023
PubMed
まとめ

科学者は新しい光制御スイッチを開発し 細胞フリー遺伝子の発現を 正確にオン・オフにしました 合成生物学におけるこの突破は 医療やナノテクノロジーにおける 先進的な応用のための 遠隔操作の 非侵襲的な制御を提供します

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Recombinant DNA01:09

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CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
Recombinant DNA01:09

Recombinant DNA

Overview
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...