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Updated: Aug 2, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

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腫瘍性CDK13変異は核RNAの監視を妨げている

Megan L Insco1,2, Brian J Abraham3, Sara J Dubbury4,5

  • 1Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|April 20, 2023
PubMed
まとめ

核RNAの監視が妨害されれば 癌が発症します サイクリン依存キナーゼ13 (CDK13) 変異はRNAの分解を阻害し,異常転写を安定させることでメラノーマを加速する.

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