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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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チロシンを含むペプチドの化学選択による酸化誘発型マクロサイクリング

E Dalles Keyes1, Marcus C Mifflin1, Maxwell J Austin1

  • 1Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States.

Journal of the American Chemical Society
|April 29, 2023
PubMed
まとめ

この研究は,タイロシン残基を選択的に結合することによって,サイクルペプチドを生成するための新しい方法を導入しています. 新しい戦略は,特定の化学反応を使用して,自然プロセスにインスパイアされた安定したチロシンに結合したサイクルペプチドを形成します.

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