関連する実験動画

Updated: Jul 31, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

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セロトニントランスポーターの構造的に選択的阻害剤の発見

Isha Singh1, Anubha Seth2, Christian B Billesbølle1

  • 1Department of Pharmaceutical Chemistry, University of California, San Francisco, 1700 4th St., Byers Hall Suite 508D, San Francisco, CA 94143, USA.

Cell
|May 3, 2023
PubMed
まとめ

新しいセロトニントランスポーター (SERT) 阻害剤は内側開かれた状態を標的として開発され,マウスでは強力な抗うつ剤と抗不安剤の効果を示した. これらの新しい化合物は,モルヒンの離脱症状を逆転させ,治療的可能性を提供しました.

キーワード:
うつ病ドッキング機能的選択性セロトニントランスポーター超大型図書館

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