皮質と皮質のフィードバックは,視覚皮質の活発なデンドライトを巻き込みます
Mehmet Fişek1, Dustin Herrmann2, Alexander Egea-Weiss2
1Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. fisekm@gmail.com.
Nature
|May 3, 2023
まとめ
主要視野皮質への高視野領域からのネオコルチカルフィードバックは空間的に組織されています. このフィードバックは,空間的にオフセットされ,デンドライトで非線形に統合することで,知覚を容易にする.
科学分野:
- 神経科学
- 視覚野の研究
- 皮質回路
背景:
- 感覚処理は新皮質のフィードバック経路に依存しています
- フィードバックは文脈的な情報を提供し,知覚を助けますが,そのメカニズムは十分に理解されていません.
研究 の 目的:
- 側中視野 (LM) から主視野皮質 (V1) へのフィードバックの影響の回路と細胞機構を調査する.
- 空間的に組織されたフィードバックが視覚的知覚にどのように貢献するのかを理解する.
主な方法:
- マウスの長距離全光学接続マッピング
- V1ピラミッドニューロンの 2フォトンのカルシウム画像
- LMニューロンを活性化する 2光子の光遺伝学です
主要な成果:
- LMからV1へのフィードバックは空間的に編成されています. 整列すると抑制され,視覚空間でオフセットすると促進されます.
- 促進フィードバックは,V1ピラミッドニューロンのアピカルタフトデンドライトに非線形に統合されています.
- LMニューロンを刺激してV1に投射すると, 枝に特異的な dendritic カルシウム信号が発せられます.
結論:
- 新皮質のフィードバック接続は空間的に組織され,文脈的な相互作用で役割を果たします.
- フィードバックの非線形 dendritic 統合は予測的および協力的知覚機能をサポートします.
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