バットASC2は炎症体を抑制し,炎症疾患を緩和する

Matae Ahn¹, Vivian Chih-Wei Chen², Pritisha Rozario²

¹Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore; SingHealth Duke-NUS Medicine Academic Clinical Program, Singapore 168753, Singapore; SingHealth PGY1 Residency Program, Singapore 169608, Singapore; Department of Internal Medicine, Singapore General Hospital, Singapore 169608, Singapore.

Cell

|May 12, 2023

まとめ

炎症性疾患やウイルス感染症の治療の可能性を提示する強力な炎症体を抑制する独特のタンパク質であるASC2を持っています

科学分野:

免疫学
ウイルス学
老化に関する研究

背景:

コウモリには驚くべき長寿とウイルスへの抵抗力があり炎症性の経路が変化していることも関連しています
炎症性疾患の管理における炎症体シグナル伝達の役割は完全に理解されていません.

研究の目的:

コウモリにおける炎症体信号伝達の新しい調節体を特定し,特徴づけること.
コウモリ由来の炎症体調節剤の治療の可能性を調査する

主な方法:

バットASC2の表現と機能を特定し特徴づけました
バットASC2のヒトとマウスの炎症体に対する抑制能力を評価した.
炎とウイルス感染モデルにおけるコウモリASC2の有効性を評価するためにマウスモデルを使用した.
バットASC2の機能強化に寄与する主要残留物を分析した.

主要な成果:

バットASC2はヒトとマウスの炎症体の両方の強力な阻害剤です.
バットASC2のトランスジェニック発現は実験的な腹膜炎とウイルス誘発の炎症を改善した.
バットASC2はインフルエンザAウイルスに感染したマウスの死亡率を低下させた.
バットASC2は,SARS-CoV-2の免疫複合体によって引き起こされる炎症体の活性化を抑制した.

結論:

バットASC2は炎症体活性化の重要な負の調節体として作用する.
バットASC2は炎症性疾患やウイルス感染症の治療に有効である.

キーワード:

コロナウイルス SARS-CoV-2についてバット病気に対する耐性免疫コンプレックス炎症ゾーム炎症炎症性疾患長生きするウイルスの貯蔵庫

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