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Updated: Jul 30, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

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自然製品にインスパイアされた潜伏電極による共性阻害

David P Byun1, Jennifer Ritchie1, Yejin Jung1

  • 1Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States.

Journal of the American Chemical Society
|May 15, 2023
PubMed
まとめ

3- ブロモ-4,5- ディヒドロイソクサゾール (BDHI) は,ヒトプロテオーム内の反応性システインを選択的に標的とする. この天然製品にインスパイアされた分子は,ハロアセタミドとは異なる選択性を提供し,共振探査と薬物の発見を可能にします.

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