C. elegansのセロトニン系の機能的組織を全脳スケールで解剖する

Ugur Dag¹, Ijeoma Nwabudike¹, Di Kang¹

¹Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Cell

|May 16, 2023

まとめ

セロトニンは脳内の特定の受容体に作用することで C. elegansの行動を調節します. この研究はセロトニン受容体の部位をマッピングし脳の活動と餌を採る行動を制御する方法を理解します

科学分野:

神経科学
行動生物学
分子生物学

背景:

セロトニンは様々な動物の行動に影響を与える重要な神経伝達物質です
脳のセロトニン受容体が全体の活動や行動を調節する正確なメカニズムはほとんど不明です

研究の目的:

セロトニンの放出が脳全体の活動を変化させ餌を求める行動を誘発する方法を調べるため
特定のセロトニン受容体を特定して移動と食事の行動を調節する.

主な方法:

核と相互作用するセロトニン受容体を特定するために包括的な遺伝分析を使用しました.
セロトニンに関連した脳動態を観察するために全脳画像を用いた.
*C. elegans*コネクトーム内のセロトニン受容体発現部位をマッピングした.

主要な成果:

3つのセロトニン核受容体 (MOD-1,SER-4,LGC-50) が特定され,セロトニンの放出時に運動を遅らせる.
この行動を調節する追加の受容体 (SER-1,SER-5,SER-7) が発見された.
SER-4は突然のセロトニン増加に対する反応を媒介し,MOD-1は持続的な放出に対する反応を媒介することが示された.
セロトニンに関連した神経動態が複数の行動ネットワークに広がっていることを明らかにした
ニューロンの活性性を予測するために,相関する受容体発現とシナプス接続性.

結論:

セロトニンはコンネクトームの特定の受容部位に作用し,脳全体の活動を調節します.
この行動は,ゆっくりと移動し,餌を与えることなどの特定の行動の誘導を支えている.
この研究は,脳全体のセロトニン受容体の機能の詳細な地図を提供します.

キーワード:

C. エレガンス行動脳全体の活動神経調節セロトニン

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