C5aライセンスファゴサイトは,全身性真菌感染中に免疫を滅菌させる

Jigar V Desai¹, Dhaneshwar Kumar², Tilo Freiwald³

¹Fungal Pathogenesis Section, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy & Infectious Diseases, NIH, Bethesda, MD, USA.

Cell

|May 23, 2023

まとめ

補足システム

科学分野:

免疫学
菌類学
感染症

背景:

組織性カンジダ症は病院で頻繁に発生する致命的な感染症です.
これは抗補足C5単体抗体療法の新たな合併症である.
これは,抗真菌免疫におけるC5の重要な役割を強調しています.

研究の目的:

全身性カンジダ症における補完体の役割を調査する.
カンジデミアを予測するバイオマーカーを特定する
C5媒介の抗真菌保護のメカニズムを解明する.

主な方法:

カンジデミア患者における遺伝子発現の分析
組織性カンジダ症のマウスモデルを用いて
宿主応答と生存に対するC5a受容体1 (C5ar1) 剥離の影響を調査する.

主要な成果:

補完系遺伝子転写は,カンジデミアの患者および予測されたカンジデミアの患者で最上位に誘発された経路でした.
C5a- C5aR1シグナリングは,ファゴシート機能と組織生存経路 (ERK,AKT) を通じて,真菌のクリアランスと宿主生存を促進しました.
C5ar1欠乏はマクロファージ代謝を変化させ,アポトーシスを誘発し,腎臓損傷による死亡率を増加させた.

結論:

局所的なファゴサイト由来C5は,ファゴサイトの最適な抗菌機能に不可欠です.
細胞によるC5の生成は,全身性菌感染症に対する先天的な保護を与えます.
白血球C5の発現に影響を与えるC5aレベルまたはC5ポリモルフィズムが低下すると,患者の不良結果と相関する.

キーワード:

C5 について C5aR1 カンジダアバコパンカンジデミアカンジディアス補足するエキュリズマブ腎臓

さらに関連する動画

07:21

Author Spotlight: Unraveling the Interplay Between Trichoderma stromaticum and the Mammalian Immune System

Published on: October 20, 2023

1.4K

11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.8K

関連する概念動画

01:31

Defense Against Bacterial Pathogens

1.5K

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

1.5K

01:25

Immune Surveillance by NK Cells and Phagocytes

1.6K

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

1.6K

01:40

Cell-mediated Immune Responses

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...

2.5K

01:27

Cytotoxic T Cells-mediated Immune Response

1.0K

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

1.0K

01:23

Antimicrobial Proteins

1.1K

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...