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Updated: Jul 29, 2025

Imaging the Human Immunological Synapse
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Published on: December 26, 2019

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エクトサイトーシスは,免疫シナプスでT細胞受容体信号を自己制限する

Jane C Stinchcombe1, Yukako Asano1, Christopher J G Kaufman1

  • 1Cambridge Institute for Medical Research, Keith Peters Building, Cambridge CB2 0XY, UK.

Science (New York, N.Y.)
|May 25, 2023
PubMed
まとめ

細胞毒性Tリンパ球 (CTLs) は,活性化されたT細胞受容体 (TCRs) をエクトソームに流すことでシグナル伝達を終了する. このプロセスは,ダイアシルグリセロール (DAG) によって媒介され,CTLがより多くの標的細胞を解除し,殺すことができます.

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