Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

34.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.8K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

94
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
94
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Narcolepsy01:07

Narcolepsy

158
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
158
Understanding Sleep01:11

Understanding Sleep

436
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
436

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Reconstruction of Ultrafine MnS-Induced Vacancy-Rich Co<sub>9</sub>S<sub>6.29</sub> Precatalysts in Mesoporous S-Doped N-Rich Hollow Carbon Nanotubes Enables Dynamic O-Vacancy Cycling for High-Performance Zn-Air Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.

Science advances·2026
Same author

Reassessing forebrain organization: recent evidence challenges the prosomere model.

Current opinion in genetics & development·2026
Same author

Isolation and Characterization of Extracellular Vesicles from Mouse Retina Tissue.

bioRxiv : the preprint server for biology·2026
Same author

Signaling and transcriptional networks governing late synovial joint development.

Developmental biology·2026
Same author

Microglial state transitions are constrained by developmental and metabolic checkpoints.

Frontiers in cellular neuroscience·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
関連記事をすべて見る

関連する実験動画

Updated: Jul 28, 2025

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.4K

スーパーソニック シルカディアンシンクロナイザー

Dong Won Kim1,2, Seth Blackshaw3,4,5,6,7

  • 1Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus, Denmark.

Science (New York, N.Y.)
|June 1, 2023
PubMed
まとめ
この要約は機械生成です。

Sonic Hedgehog (SHH) のシグナル伝達とプライマリシリアは哺乳類の昼夜時計の重要なレギュレーターであり,日々の生物学的リズムに影響を及ぼします. この研究は,身体の内部タイムキーピングメカニズムを維持する上で,それらの基本的な役割を強調しています.

さらに関連する動画

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

関連する実験動画

Last Updated: Jul 28, 2025

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
05:46

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents

Published on: January 24, 2013

21.4K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

科学分野:

  • 細胞生物学
  • クロノバイオロジー
  • 分子生物学

背景:

  • 生理時計は哺乳類の日常の生理リズムと 行動リズムを制御します
  • プライマリーシリアは様々な信号伝達経路に関与する 感覚器官として知られています
  • シルカディアンリズム調節におけるソニック・ヘッジホッグ (SHH) 信号の役割は完全に理解されていません.

研究 の 目的:

  • サニック・ヘッジホッグ (SHH) 信号が哺乳類の昼夜時計の調節に関与することを調査する.
  • 昼夜計時という文脈でプライマリシリアの機能を解明する.

主な方法:

  • SHHシグナル伝達やプライマリシリア機能の障害のある遺伝的マウスモデルを使用した.
  • 時計遺伝子発現の 分子と生化学分析を行った.
  • 行動リズムと生理学的パラメータを評価した.

主要な成果:

  • SHHのシグナル伝達経路の破壊は,日中時計の遺伝子発現を著しく変えた.
  • 主要な乳毛の機能が低下すると,昼夜リズムが失調する.
  • SHHのシグナリングコンポーネントは,コアクロックメカニズム内に局所されていることが判明しました.

結論:

  • ソニック・ヘッジホッグ (SHH) 信号は哺乳類の昼夜時計を制御する重要な経路です.
  • 主要なシリアは,SHH依存の昼夜調節を媒介する上で重要な役割を果たします.
  • これらの発見は 生物学的時間測定の基礎にある 新しい分子機構を明らかにしています