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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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イン シチュー ポリメリゼーション媒介抗原表示

Chao Pan1, Lu Wang1, Mengmeng Zhang1

  • 1Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Journal of the American Chemical Society
|June 1, 2023
PubMed
まとめ
この要約は機械生成です。

新しい in situ ポリメリゼーション媒介抗原プレゼンテーション (IPAP) 方法は,ナノワクチンをデンドリット細胞に固定することで,適応免疫を強化します. このアプローチは抗原のプレゼンテーションを改善し,病気の免疫のための強力な免疫反応を誘発します.

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In Situ MHC-tetramer Staining and Quantitative Analysis to Determine the Location, Abundance, and Phenotype of Antigen-specific CD8 T Cells in Tissues
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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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関連する実験動画

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Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
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In Situ MHC-tetramer Staining and Quantitative Analysis to Determine the Location, Abundance, and Phenotype of Antigen-specific CD8 T Cells in Tissues
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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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科学分野:

  • 免疫学
  • ナノテクノロジー
  • バイオ材料

背景:

  • 適応免疫は,抗原を提示する細胞の有効な活性化に依存しています.
  • 従来の戦略では,しばしば抗原特異的プリミングが不十分であることが示されます.
  • 抗原表現と免疫反応を高めるための改善された方法が必要である.

研究 の 目的:

  • 適応性免疫の強化のためのインサイトポリメリゼーション媒介抗原プレゼンテーション (IPAP) の開発と評価.
  • dendritic 細胞による抗原プレゼンテーションの改善における IPAP のメカニズムを調査する.
  • 腫瘍とウイルス抗原に対する抗原特異免疫反応を誘発するIPAPの有効性を評価する.

主な方法:

  • ドーパミンで in situ ポリメリゼーションによって形成された抗原を積んだナノワクチンの開発.
  • ナノワクチンが dendritic 細胞に in vivo 固定される.
  • 抗原の吸収,分解,表示の評価
  • ネズミのモデルにおける細胞および体内免疫を含む免疫反応の評価.
  • オバルブミンとSARS-CoV-2 スパイクタンパク質S1サブユニットでIPAPを検査する.

主要な成果:

  • IPAPは自発的にナノワクチンを形成し,その細胞を体内に固定します.
  • 化学的に結合したナノワクチンはマクロピノサイトーシスを強化し,抗原の分解を減少させます.
  • IPAPは注射部位での抗原保持を延長し,リンパ節の蓄積を改善する.
  • オバルブミンを発現する腫瘍に対する有意な保護免疫が観察されました.
  • SARS-CoV-2 スパイクタンパク質S1サブユニットを用いて,S1特異の免疫グロブリンGの産生を増加させました.

結論:

  • IPAPは,抗原を提示する細胞を刺激するための簡単で汎用的な戦略を提供します.
  • この方法は,抗原特異の適応免疫反応を効果的に強化します.
  • IPAPは様々な病気に対する予防接種に 有望なアプローチを示しています