SARS-CoV-2 感染症の急性後遺症の定義の開発
Tanayott Thaweethai1,2, Sarah E Jolley3, Elizabeth W Karlson4
1Massachusetts General Hospital, Boston.
JAMA
|June 6, 2023
まとめ
SARS-CoV-2 感染症の後急性症候群 (PASC),または長期COVIDは,37の症状が特定された多くの個人に影響します. 感染後6ヶ月で10%の陽性と診断された前向きな研究では,症状に基づいてPASCが定義されました.
科学分野:
- 感染症
- 公衆衛生
- 臨床医学
背景:
- SARS-CoV-2感染後の持続的な症状は,SARS-CoV-2感染 (PASC) または長期COVIDの後遺症として知られており,標準化された特徴づけを必要とします.
- PASCを理解するには,多様な集団から将来的に統一的に収集されたデータの分析が不可欠です.
研究 の 目的:
- 自己報告された症状を利用したPASCの定義を確立する.
- 異なる人口集団,ワクチン接種状況,感染歴におけるPASCの頻度を決定する.
主な方法:
- 米国とプエルトリコの85カ所の成人9,764人を対象とした前向きな観察コホート研究.
- 参加者は,急性SARS-CoV-2感染発症または診断から少なくとも6ヶ月後に症状調査を完了しました.
- データ収集には,人口ベースの,ボランティアの,および便利なサンプリング方法が含まれています.
主要な成果:
- 37の症状に対する調整された確率比は,感染した対未感染の参加者において1. 5またはそれ以上であった.
- PASCに寄与する主な症状は,運動後の不快感,疲労,脳霧,胃腸の問題でした.
- 2021年12月1日以降に感染した参加者のうち,10%が6ヶ月後にPASCと特定されました.
結論:
- PASCの予備的な定義は,大規模な前向きなコホートからの症状データに基づいて開発されています.
- 実行可能なPASCの定義を作成するには,追加の臨床的特徴を組み込むためのさらなる精細化が必要です.
- この研究は,将来のPASC研究と臨床定義のための基礎的枠組みを提供します.
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