関連する実験動画

Updated: Jan 18, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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細胞内アゴニストによるクラスB1のGPCR活性化

Kazuhiro Kobayashi1, Kouki Kawakami2, Tsukasa Kusakizako1

  • 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Nature
|June 7, 2023
PubMed
まとめ

研究者らは,Gタンパク質結合受容体 (GPCR) に新しい細胞内結合ポケットを発見した. この発見はバイアスアゴニストが 選択的にシグナル伝達経路を活性化し 新しい薬の開発の道を開くことを明らかにしています

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