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Updated: Jul 26, 2025

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

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CRISPRトリマー・インテグラーゼによるゲノム拡張

Joy Y Wang1,2, Owen T Tuck1,2, Petr Skopintsev2,3,4

  • 1Department of Chemistry, University of California, Berkeley, CA, USA.

Nature
|June 14, 2023
PubMed
まとめ

CRISPR-Casシステムは新しいトリマー・インテグラーゼ酵素を用いて,Cas1-Cas2をエクソヌクレアゼと融合させ,外来DNAを正確に捕捉して統合します. このメカニズムは自己DNAの保護を保証し,Cas4が欠けている微生物の自己免疫反応を防止します.

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