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Updated: Jul 26, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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初期前立腺がんおよびCTCにおける抗腫瘍免疫遺伝子の静止作用

Hongshan Guo1, Joanna A Vuille2, Ben S Wittner2

  • 1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Cell
|June 16, 2023
PubMed
まとめ

前立腺がんの初期段階では 免疫遺伝子のCD1やIFI16を 静止させることで DNAの低甲基化が起こります これらの遺伝子をマウスで再活性化することで 腫瘍の成長が止まり 癌に対する免疫の表遺伝子が 明らかになりました

キーワード:
CD1ADNAヒポメチル化IFI16 についてNKT細胞循環する腫瘍細胞免疫監視脂質抗原前立腺がん単細胞シーケンシング腫瘍発生

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