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Updated: Jul 26, 2025

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
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Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase

Published on: March 19, 2020

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開いた金属の調整部位に隣接する調節可能な基板結合ポケットを持つヘム酵素の設計

Indrek Kalvet1,2,3, Mary Ortmayer4, Jingming Zhao4

  • 1Institute for Protein Design, University of Washington, 3946 W Stevens Way NE, Seattle, Washington 98195, United States.

Journal of the American Chemical Society
|June 21, 2023
PubMed
まとめ

科学者は新しいヘム結合タンパク質 dnHEM1 を設計し,シトクロームP450sを模倣した. このタンパク質構造は,プロフェンスの過酸化とエナチオセレクティブのカーベノトランスファーゼ機能を含む多様な触媒活動のためのカスタム酵素設計を可能にします.

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