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CD19-CAR T細胞を標的にして,抗合成症候群に関連した筋膜炎および間隔性肺疾患
Ann-Christin Pecher1, Luca Hensen1, Reinhild Klein1
1Department of Internal Medicine II, Hematology, Oncology, Clinical Immunology, and Rheumatology, University Hospital Tübingen, Tübingen, Germany.
JAMA
|June 27, 2023
まとめ
CD19を標的とするCAR T細胞治療は,耐火性抗合成酵素症候群において有望である. この治療は,重大な症例において,臨床的に有意な改善をもたらし,重要なバイオマーカーを正常化した.
科学分野:
- 免疫学
- 細胞療法
- リウマトロジ
背景:
- 抗合成酵素症候群は,骨髄炎と間隔性肺疾患によって特徴づけられる重度の自己免疫疾患である.
- 耐火性の症例は重要な課題となり,新しい治療戦略が必要となる.
- CD19を標的にするキメリック抗原受容体 (CAR) T細胞は,潜在的な免疫抑制剤として出現した.
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