巣立っていたプロトセルコミュニティへの自律的統合

Zhuping Yin¹, Ning Gao^1,2, Can Xu¹

¹Centre for Protolife Research, School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

Journal of the American Chemical Society

|June 27, 2023

まとめ

研究者は自己組織化した巣に囲まれたプロトセルコミュニティを作り多細胞システムを模倣しましたこれらの人工細胞コミュニティは協調した機能を示し需要に応じて安定化または解体することができます

科学分野:

バイオミメティック材料科学
合成生物学
柔らかい物質の物理

背景:

モデル原細胞は生命の起源を理解し人工的な細胞システムを構築するためのプラットフォームを提供します
合成細胞で協調した行動と高度な組織を達成することは依然として大きな課題です

研究の目的:

シンビオティックな原生細胞のコミュニティを作るための半自律的なメカニズムを開発する
人工細胞システムの自己組織化と機能的統合を研究する.
複雑な構造と機能を持つ再構成可能な細胞模倣材料を設計する.

主な方法:

アルギナット/シルク・フィブロイン・コアセルバート・ベシクル内のタンパク質を捕獲するためのエンドシンビオティックのような経路を利用した.
酵素活性 (ウレアゼ/グルコース酸化酶) によって媒介されるコアセルバト胞の形態の変化が実証された.
自動運転能力のための燃料駆動プロセスと構造的安定化のための酵素媒介マトリックス強化を導入した.

主要な成果:

統合された触媒活動を持つプロト細胞の離散的な巣のコミュニティを成功裏に形成しました
これらのコミュニティの選択的な崩壊を示しました
ダイペプチドの超分子組立とチラミン-アルギナートクロスリンクを通じて構造的安定化を達成した.
内部化された粉水溶液による自己駆動能力の調節が実証された.

結論:

この研究は,共生的な細胞のような巣のコミュニティを構築するための新しい半自律的なメカニズムを提示しています.
この研究は,人工的多細胞性および再構成可能な細胞模倣物質の開発を進めています.
構造的,機能的,組織的な複雑性を持つ材料を作成するための道を開きます.

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