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Radical Reactivity: Steric Effects01:10

Radical Reactivity: Steric Effects

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The presence of electron-donating, electron-withdrawing, or conjugating groups adjacent to a radical center, imparts electronic stabilization to the radicals. Examples of such electronically-stabilized radicals are triphenylmethyl, tetramethylpiperidine‐N‐oxide, and 2,2‐diphenyl‐1‐picrylhydrazyl. These radicals are remarkably stable and are known as persistent radicals. Some of the persistent radicals can even be isolated and purified.
Along with electronic...
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Radical Reactivity: Overview01:11

Radical Reactivity: Overview

2.1K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
2.1K
Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

13.2K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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Phosphorylation01:02

Phosphorylation

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Radical Reactivity: Electrophilic Radicals01:02

Radical Reactivity: Electrophilic Radicals

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Radicals adjacent to electron‐withdrawing groups are called electrophilic radicals. These radicals readily react with nucleophilic alkenes. For example, the malonate radical, in which the radical center is flanked by two electron‐withdrawing groups, reacts readily with butyl vinyl ether, which consists of an electron‐donating oxygen substituent. The reaction between electrophilic malonate radical and nucleophilic vinyl ether is favored because the radical has a...
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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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Updated: Jul 24, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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ステレオ制御によるラジカルチオフォスホルリレーション

Molhm Nassir1, Michał Ociepa1, Hai-Jun Zhang1

  • 1Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|July 3, 2023
PubMed
まとめ

この研究は,リモネン由来の反応剤を用いた最初のステレオ選択的P ((V)) 基の水酸化を導入する. これらの反応剤はオレフィンからP-キラルビルディングブロックを作り,新しい化学空間を探索するための新しい経路を提供します.

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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

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Identification of Post-translational Modifications of Plant Protein Complexes
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Identification of Post-translational Modifications of Plant Protein Complexes

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科学分野:

  • 有機化学
  • オルガノフォスファース化学
  • ステレオ選択合成

背景:

  • (V) 化学は独特の性質を備えているが,十分に研究されていない.
  • キラル有機リン化合物のステレオ選択的合成は依然として課題である.

研究 の 目的:

  • 実践的で完全にステレオセレクティブなP ((V) 根の水素酸化反応を開発する.
  • 薬の発見と材料科学のための新しいP-キラルビルディングブロックを作成します.

主な方法:

  • 単純でリモネン製の反応剤をP (V) 基の水素酸化に使用した.
  • オレフィンや他のラジカル受容体と反応するレアジェンスを用いる.
  • P-キラル製品の多様化のための従来の2e化学を応用した.

主要な成果:

  • 完全ステレオセレクティブのP (V) 根の水酸化を初めて実現した.
  • 未知のP-キラル バイオイソステリックの構成要素を 生成した.
  • 計算と実験によって支持された,予期せぬステレオ化学的結果を持つ,幅広い範囲と優れた化学選択性を実証した.

結論:

  • 開発された方法論は,P-キラル化合物への新しい効率的な経路を提供します.
  • 生成された構成要素は 可能性のある応用がある めったに探求されていない 化学領域を表しています
  • 最初のADME研究は,さらなる調査のための有利な性質を示唆しています.