関連する実験動画
Updated: May 3, 2026

07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
28.4K
生まれつきの心臓障害を持つ人の出生から若年期までの生存率:CH STRONG
Karrie F Downing1, Wendy N Nembhard2, Charles E Rose1
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA (K.F.D., C.E.R., M.E.O., S.L.F.).
Circulation
|July 4, 2023
まとめ
1980年から1997年の間に米国で生まれた先天性心疾患 (CHD) の10人に8人は35歳まで生存しました. 生存率は,心臓病の重度,他の異常の存在,出生体重,母親の人種/民族によって変化した.
科学分野:
- 心臓病科
- 公衆衛生
- 小児科
背景:
- 生まれながらの心疾患 (CHD) の米国人の長期的な生存に関する人口ベースのデータは限られている.
- 生存パターンと関連する要因を理解することは この集団のケアと結果を改善するために不可欠です
研究 の 目的:
- 慢性疾患患者の米国の人口サンプルで,出生から35歳までの長期生存パターンを評価する.
- 心臓病患者の生存率と死亡率に関連する要因を特定する.
主な方法:
- 1980年から1997年の間に生まれました.
- 2015年までのCHDデータと死亡記録をリンクし,生存状況と死亡年数を決定しました.
- カプラン・マイヤー生存曲線,調整されたリスク比率 (aRRs),およびコックス比例危険比率 (aHRs) を使って生存と死亡率の要因を分析した.
主要な成果:
- 35歳までの全生存率は,心臓病患者の81. 4%でした.
- 重度の心臓病,遺伝的症候群,非心臓異常,低出生体重,特定の母親の人種/民族は,乳児死亡率の増加と長期生存率の低下と関連していました.
- 心臓病患者の乳児および幼児死亡率は一般人群と比較して高かったが,死亡率は非心臓病またはより軽度の心臓病の患者では一般人群のレベルに接近した.
結論:
- 1980年から1997年の間に生まれた心臓病の患者の約80%は,若い成人期 (35歳) まで生き延びました.
- 生存の格差は,CHDの重症度,同時発生の異常,出生体重,母親の人種/民族性に関連していました.
- 心臓疾患以外の個体では,1歳から35歳までの死亡率は一般人群と同等であり,同時に発生する疾患が長期的な結果に与える影響を強調した.
関連する概念動画
Cardiopulmonary Resuscitation I: Adult
1.3K
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
1.3K
Heart Failure II: Pathophysiology
1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Cardiomyopathy I: Introduction and Classification
826
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
826
Cardiomyopathy II: Dilated Cardiomyopathy
790
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
790
Cardiomyopathy III: Hypertrophic Cardiomyopathy
805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
Cardiomyopathy IV: Restrictive Cardiomyopathy
952
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
952

