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Updated: Jul 24, 2025

Purification of Hsp104, a Protein Disaggregase
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Purification of Hsp104, a Protein Disaggregase

Published on: September 30, 2011

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ヒトの小熱ショックタンパク質B8は,本来の折り畳みプロセスに影響を与えることなく,タンパク質の結合を抑制する

Dhawal Choudhary1,2,3, Laura Mediani4, Mario J Avellaneda3

  • 1Department of Physics, Informatics and Mathematics, University of Modena and Reggio Emilia, 41125 Modena, Italy.

Journal of the American Chemical Society
|July 6, 2023
PubMed
まとめ

小型ヒートショックタンパク質 (sHSP) は,未折たタンパク質を安定化させることではなく,初期段階の積分に結合することによってタンパク質の結合を防ぐ. 病気に関連した突然変異は,この重要な抗集積機能を損なう.

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