カッシング 症候群: 概要
PubMedで要約を見る
まとめ
この要約は機械生成です。長期にわたる高コルチゾールに起因するカッシング症候群は 年間100万人に2~8人が発症します この内分泌の障害を治療するには 手術,薬,放射線が必要です.
科学分野
- 内分泌学
- 内科 医学
背景
- カッシング症候群は,生理的な理由によるものではない,長期間血コルチゾールの上昇を伴う.
- 外因的なステロイドの使用は一般的ですが,内因的なコルチゾールの過剰生産は年間100万人に2〜8人に影響します.
- 関連する症状には,高血糖症,高血圧,体重増加,気分障害があります.
研究 の 目的
- クッシング症候群とその原因を定義する.
- ハイパーコルチゾル症の診断方法の概要
- クッシング症候群の詳細な管理戦略について
主な方法
- 検診には24時間の尿中のフリーコルチゾール,深夜の唾液中のコルチゾール,またはデキサメタゾンの抑制検査が含まれます.
- プラズマのコルチコトロピンのレベルは 副腎とピトピータの原因を区別する.
- 画像検査 (MRI,ペトロサルシヌス採取,副腎/体スキャン) で腫瘍の発生源が特定される.
主要な成果
- カッシング病は下垂体腫瘍の原因で,内在的な症例の60~70%を占める.
- 特徴的な症状には,皮膚の変化 (斑点,) と代謝問題 (高血糖症,高血圧) が含まれる.
- コルチゾールの過剰産生を特定する
結論
- 内在的なカッシング症候群の第一線治療は,腫瘍の外科的除去です.
- 薬,放射線,または双方の腎上腺切除は反応しない症例の選択肢です.
- 効果的な管理には コルチゾール過剰の原因を 解決する必要があります
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