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関連する概念動画

Tissues01:18

Tissues

Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

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Published on: September 5, 2018

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単細胞 の 空間 的 転写 群 は,マカク の 皮質 の 細胞 型 の 組織 を 明らかに し て い ます

Ao Chen1, Yidi Sun2, Ying Lei3

  • 1BGI-Shenzhen, Shenzhen 518103, China; Department of Biology, University of Copenhagen, Copenhagen 2200, Denmark; BGI Research-Southwest, BGI, Chongqing 401329, China; JFL-BGI STOmics Center, Jinfeng Laboratory, Chongqing 401329, China.

Cell
|July 13, 2023
PubMed
まとめ
この要約は機械生成です。

研究者はマカクの脳皮質に 264種類の細胞をマッピングしました この脳アトラスは 脳の階層に関連した細胞分布を明らかにし 霊長類特有の細胞タイプを特定し 将来の神経科学の研究を支援します

キーワード:
細胞型組織階層構造マカクの皮質シングルセル空間トランスクリプトーム

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Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
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Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing DIVA-Seq
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関連する実験動画

Last Updated: May 13, 2026

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科学分野:

  • 神経科学
  • ゲノミクス
  • 細胞生物学

背景:

  • 脳皮質の細胞組織を理解することは 脳機能の鍵です
  • これまでの研究では 細胞の種類と空間分布の 詳細な地図がありませんでした

研究 の 目的:

  • マカクの皮質細胞の種類とその空間的組織を詳細にアトラスを作成する.
  • 細胞の分布,皮質の階層,霊長類特有の細胞の間の関係を調査する.

主な方法:

  • 大規模な単核RNAの配列解析
  • 143のマカクの皮質領域にわたる空間的トランスクリプトミア分析
  • 種間トランスクリプトミックの比較 (ヒト,マカク,マウス).

主要な成果:

  • トランスクリプトームで定義された264種類の皮質細胞の総合アトラス.
  • マカクの皮質の細胞の空間分布をマッピングした.
  • 細胞分布,地域的階層,霊長類特異的な細胞タイプの間のリンクが層4で強化されました.

結論:

  • 霊長類の脳の進化,発達,病気の 細胞と分子基盤を提供する.
  • 皮質機能における空間的組織の重要性を強調する.
  • 地域依存の遺伝子発現を持つ新種の霊長類特有の細胞タイプを識別する.